Interações medicamentosas
Atazanavir + Cariprazine
Gravidade: Grave
Atazanavir and Cariprazine: major interaction.
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Resumo
Atazanavir is a strong CYP3A4 inhibitor and can raise cariprazine and its active metabolites, which have long half-lives. This increases the risk of akathisia, extrapyramidal symptoms, sedation and metabolic effects.
O que esta interação significa em palavras simples
Atazanavir and Cariprazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atazanavir belongs to Anti Virals; Cariprazine belongs to Central Nervous System.
Por que acontece
Inhibition of CYP3A4, the main route of cariprazine metabolism.
O que fazer
If starting cariprazine in a patient on atazanavir, use half the usual dose; if starting atazanavir in a patient on cariprazine, reduce the cariprazine dose by half (every other day if on 1.5 mg daily). Monitor for adverse effects for several weeks given the long half-life.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Cariprazine
Outras interações de Atazanavir
- Alfuzosin + Atazanavir Contraindicada
- Atazanavir + Avanafil Contraindicada
- Atazanavir + Dronedarone Contraindicada
- Atazanavir + Eletriptan Contraindicada
- Atazanavir + Eplerenone Contraindicada
- Atazanavir + Ergotamine Contraindicada
Perguntas frequentes
Can I take Atazanavir with Cariprazine?
MediHelp rates the interaction as major. Atazanavir and Cariprazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Atazanavir is a strong CYP3A4 inhibitor and can raise cariprazine and its active metabolites, which have long half-lives. This increases the risk of akathisia, extrapyramidal symptoms, sedation and metabolic effects.
How serious is the interaction between Atazanavir and Cariprazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If starting cariprazine in a patient on atazanavir, use half the usual dose; if starting atazanavir in a patient on cariprazine, reduce the cariprazine dose by half (every other day if on 1.5 mg daily). Monitor for adverse effects for several weeks given the long half-life.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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