Interações medicamentosas
Benzhydrocodone / acetaminophen + Cariprazine
Gravidade: Grave
Benzhydrocodone / acetaminophen and Cariprazine: major interaction.
Última atualização Fontes: UK SmPC
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Cariprazine combined with an opioid such as benzhydrocodone may cause additive sedation, respiratory depression, coma and death in severe cases. Impaired psychomotor performance is also expected.
O que esta interação significa em palavras simples
Benzhydrocodone / acetaminophen and Cariprazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive CNS and respiratory depression from opioid agonism and antipsychotic sedation.
O que fazer
Reserve the combination for patients without adequate alternatives, limit dose and duration, and monitor for sedation and respiratory depression.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Cariprazine
Perguntas frequentes
Can I take Benzhydrocodone / acetaminophen with Cariprazine?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Cariprazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cariprazine combined with an opioid such as benzhydrocodone may cause additive sedation, respiratory depression, coma and death in severe cases. Impaired psychomotor performance is also expected.
How serious is the interaction between Benzhydrocodone / acetaminophen and Cariprazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients without adequate alternatives, limit dose and duration, and monitor for sedation and respiratory depression.
What other medicines interact with Cariprazine?
MediHelp also lists interactions of Cariprazine with, for example, Alfentanil, Amisulpride, Amobarbital. The full list is on the Cariprazine page.
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