Interações medicamentosas
Atidarsagene autotemcel + Efavirenz
Gravidade: Grave
Atidarsagene autotemcel and Efavirenz: major interaction.
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Resumo
Antiretrovirals may impair lentiviral transduction of the patient's collected hematopoietic cells and interfere with manufacture of the gene therapy, which could reduce its effectiveness.
O que esta interação significa em palavras simples
Atidarsagene autotemcel and Efavirenz can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atidarsagene autotemcel belongs to Miscellaneous; Efavirenz belongs to Anti Virals.
Por que acontece
Reverse transcriptase inhibitors can interfere with lentiviral vector transduction during cell manufacturing.
O que fazer
Stop efavirenz at least 1 month before cell mobilization, allowing for its long elimination time, and keep it off through apheresis. Arrange alternative HIV management with a specialist.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Efavirenz
- Cobimetinib + Efavirenz Contraindicada
- Dienogest / estradiol valerate + Efavirenz Contraindicada
- Dihydroergotamine intranasal + Efavirenz Contraindicada
- Dihydroergotamine + Efavirenz Contraindicada
- Doravirine + Efavirenz Contraindicada
- Efavirenz + Elbasvir / grazoprevir Contraindicada
Outras interações de Atidarsagene autotemcel
Perguntas frequentes
Can I take Atidarsagene autotemcel with Efavirenz?
MediHelp rates the interaction as major. Atidarsagene autotemcel and Efavirenz can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antiretrovirals may impair lentiviral transduction of the patient's collected hematopoietic cells and interfere with manufacture of the gene therapy, which could reduce its effectiveness.
How serious is the interaction between Atidarsagene autotemcel and Efavirenz?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop efavirenz at least 1 month before cell mobilization, allowing for its long elimination time, and keep it off through apheresis. Arrange alternative HIV management with a specialist.
What other medicines interact with Efavirenz?
MediHelp also lists interactions of Efavirenz with, for example, Cobimetinib, Dienogest / estradiol valerate, Dihydroergotamine intranasal. The full list is on the Efavirenz page.
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