Interações medicamentosas
Atidarsagene autotemcel + Raltegravir
Gravidade: Grave
Atidarsagene autotemcel and Raltegravir: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Antiretroviral drugs can interfere with the manufacture of this lentiviral gene therapy by inhibiting transduction of mobilized cells. Raltegravir, an integrase inhibitor, may reduce the efficiency of vector integration.
O que esta interação significa em palavras simples
Atidarsagene autotemcel and Raltegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Atidarsagene autotemcel belongs to Miscellaneous; Raltegravir belongs to Anti Virals.
Por que acontece
Antiretrovirals inhibit lentiviral vector transduction of harvested stem cells during manufacturing.
O que fazer
Stop raltegravir at least one month before mobilization, or longer to cover drug elimination, and keep it off through apheresis. Arrange alternative HIV management with the treating team.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Raltegravir
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Raltegravir Contraindicada
- Aluminum hydroxide / magnesium carbonate + Raltegravir Grave
- Aluminum hydroxide / magnesium trisilicate + Raltegravir Grave
- Aluminum hydroxide + Raltegravir Grave
- Betibeglogene autotemcel + Raltegravir Grave
- Cabotegravir + Raltegravir Grave
Outras interações de Atidarsagene autotemcel
Perguntas frequentes
Can I take Atidarsagene autotemcel with Raltegravir?
MediHelp rates the interaction as major. Atidarsagene autotemcel and Raltegravir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Antiretroviral drugs can interfere with the manufacture of this lentiviral gene therapy by inhibiting transduction of mobilized cells. Raltegravir, an integrase inhibitor, may reduce the efficiency of vector integration.
How serious is the interaction between Atidarsagene autotemcel and Raltegravir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop raltegravir at least one month before mobilization, or longer to cover drug elimination, and keep it off through apheresis. Arrange alternative HIV management with the treating team.
What other medicines interact with Raltegravir?
MediHelp also lists interactions of Raltegravir with, for example, Elvitegravir / cobicistat / emtricitabine / tenofovir df, Aluminum hydroxide / magnesium carbonate, Aluminum hydroxide / magnesium trisilicate. The full list is on the Raltegravir page.
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