Interações medicamentosas
Azathioprine + Enalapril-hydrochlorothiazide
Gravidade: Grave
Azathioprine and Enalapril-hydrochlorothiazide: major interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
ACE inhibitors given with azathioprine have been associated with anemia and leukopenia, particularly in renal impairment or transplant recipients. The effect can be significant and may require dose reduction or discontinuation of one drug.
O que esta interação significa em palavras simples
Azathioprine and Enalapril-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Azathioprine belongs to Gastrointestinal Tract; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Por que acontece
ACE inhibitors may reduce erythropoietin and bone marrow response, adding to azathioprine myelosuppression; mechanism not fully established.
O que fazer
Monitor complete blood counts regularly, especially during initiation. Reduce or stop azathioprine if cytopenias develop.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Azathioprine e Enalapril-hydrochlorothiazide, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 7 dias na web. Sem cartão.
Referências
Outras interações de Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicada
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicada
- Enalapril-hydrochlorothiazide + Protein a column Contraindicada
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicada
- Amifostine + Enalapril-hydrochlorothiazide Grave
- Amiloride + Enalapril-hydrochlorothiazide Grave
Outras interações de Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicada
- Azathioprine + Bcg vaccine live Contraindicada
- Azathioprine + Febuxostat Contraindicada
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicada
- Azathioprine + Measles mumps and rubella vaccine Contraindicada
- Azathioprine + Measles mumps and rubella vaccine live Contraindicada
Perguntas frequentes
Can I take Azathioprine with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as major. Azathioprine and Enalapril-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. ACE inhibitors given with azathioprine have been associated with anemia and leukopenia, particularly in renal impairment or transplant recipients. The effect can be significant and may require dose reduction or discontinuation of one drug.
How serious is the interaction between Azathioprine and Enalapril-hydrochlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts regularly, especially during initiation. Reduce or stop azathioprine if cytopenias develop.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
