Interações medicamentosas
Azathioprine + Febuxostat
Gravidade: Contraindicada
Azathioprine and Febuxostat: contraindicated interaction.
Última atualização Fontes: US FDA label
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Resumo
Febuxostat inhibits xanthine oxidase and can raise levels of azathioprine's active metabolite, potentially causing severe bone marrow suppression. Labeling advises against use together because no safe dosing strategy is established. Patients with renal impairment or low TPMT activity are at particular risk.
O que esta interação significa em palavras simples
Azathioprine and Febuxostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Azathioprine belongs to Gastrointestinal Tract; Febuxostat belongs to Genitourinary.
Por que acontece
Febuxostat inhibits xanthine oxidase, which is needed to inactivate 6-mercaptopurine, leading to accumulation of active thiopurine metabolites.
O que fazer
Do not combine. Use an alternative urate-lowering approach, such as allopurinol with a substantial azathioprine dose reduction and close blood count monitoring, or another agent.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Referências
- Febuxostat (Uloric) Prescribing Information - Drug Interactions — FDA Label
- Adenuric (febuxostat) Summary of Product Characteristics — EMA SmPC
Outras interações de Febuxostat
- Febuxostat + Mercaptopurine Contraindicada
- Didanosine + Febuxostat Grave
- Apalutamide + Febuxostat Moderada
- Ethambutol + Febuxostat Moderada
- Febuxostat + Theophylline Moderada
Outras interações de Azathioprine
- Adenovirus types 4 and 7 live + Azathioprine Contraindicada
- Azathioprine + Bcg vaccine live Contraindicada
- Azathioprine + Influenza virus vaccine quadrivalent intranasal Contraindicada
- Azathioprine + Measles mumps and rubella vaccine Contraindicada
- Azathioprine + Measles mumps and rubella vaccine live Contraindicada
- Azathioprine + Measles mumps rubella and varicella vaccine live Contraindicada
Perguntas frequentes
Can I take Azathioprine with Febuxostat?
MediHelp rates the interaction as contraindicated. Azathioprine and Febuxostat are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Febuxostat inhibits xanthine oxidase and can raise levels of azathioprine's active metabolite, potentially causing severe bone marrow suppression. Labeling advises against use together because no safe dosing strategy is established. Patients with renal impairment or low TPMT activity are at particular risk.
How serious is the interaction between Azathioprine and Febuxostat?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine. Use an alternative urate-lowering approach, such as allopurinol with a substantial azathioprine dose reduction and close blood count monitoring, or another agent.
What other medicines interact with Febuxostat?
MediHelp also lists interactions of Febuxostat with, for example, Mercaptopurine, Didanosine, Apalutamide. The full list is on the Febuxostat page.
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