Drug interactions
Azilsartan-chlorthalidone + Calcium carbonate
Severity: Moderate
Azilsartan-chlorthalidone and Calcium carbonate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chlorthalidone decreases urinary calcium excretion, and with calcium supplements this can lead to hypercalcemia. High calcium carbonate doses may also cause metabolic alkalosis, particularly with alkali intake.
What this interaction means in plain words
Azilsartan-chlorthalidone and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Azilsartan-chlorthalidone belongs to Cardiovascular; Calcium carbonate belongs to Gastrointestinal Tract.
Why it happens
Thiazide-like reduction of renal calcium excretion adds to calcium load from supplementation.
What to do
Monitor serum calcium periodically and reduce calcium dose if levels rise. Use caution with high doses, especially in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Azilsartan-chlorthalidone
Other interactions of Calcium carbonate
Frequently asked questions
Can I take Azilsartan-chlorthalidone with Calcium carbonate?
MediHelp rates the interaction as moderate. Azilsartan-chlorthalidone and Calcium carbonate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Chlorthalidone decreases urinary calcium excretion, and with calcium supplements this can lead to hypercalcemia. High calcium carbonate doses may also cause metabolic alkalosis, particularly with alkali intake.
How serious is the interaction between Azilsartan-chlorthalidone and Calcium carbonate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum calcium periodically and reduce calcium dose if levels rise. Use caution with high doses, especially in renal impairment.
What other medicines interact with Azilsartan-chlorthalidone?
MediHelp also lists interactions of Azilsartan-chlorthalidone with, for example, Aliskiren, Sparsentan, Aceclofenac. The full list is on the Azilsartan-chlorthalidone page.
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