Interações medicamentosas
Bacitracin + Carboplatin
Gravidade: Grave
Bacitracin and Carboplatin: major interaction.
Última atualização Fontes: US FDA label
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Resumo
Systemic bacitracin is markedly nephrotoxic, and carboplatin is cleared by the kidneys. Together they may cause renal impairment and heightened carboplatin toxicity.
O que esta interação significa em palavras simples
Bacitracin and Carboplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bacitracin belongs to Miscellaneous; Carboplatin belongs to Oncology.
Por que acontece
Additive nephrotoxicity with reduced carboplatin clearance.
O que fazer
Avoid systemic bacitracin in patients receiving carboplatin and choose another antibiotic. If unavoidable, monitor renal function and adjust carboplatin dosing.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Carboplatin
Outras interações de Bacitracin
- Bacitracin + Cidofovir Contraindicada
- Adefovir + Bacitracin Grave
- Aldesleukin + Bacitracin Grave
- Amikacin + Bacitracin Grave
- Bacitracin + Cisplatin Grave
- Bacitracin + Colistin Grave
Perguntas frequentes
Can I take Bacitracin with Carboplatin?
MediHelp rates the interaction as major. Bacitracin and Carboplatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic bacitracin is markedly nephrotoxic, and carboplatin is cleared by the kidneys. Together they may cause renal impairment and heightened carboplatin toxicity.
How serious is the interaction between Bacitracin and Carboplatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic bacitracin in patients receiving carboplatin and choose another antibiotic. If unavoidable, monitor renal function and adjust carboplatin dosing.
What other medicines interact with Carboplatin?
MediHelp also lists interactions of Carboplatin with, for example, Adenovirus types 4 and 7 live, Amikacin, Amphotericin b deoxycholate. The full list is on the Carboplatin page.
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