Interações medicamentosas
Bacitracin-neomycin-polymyxin + Cidofovir
Gravidade: Grave
Bacitracin-neomycin-polymyxin and Cidofovir: major interaction.
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Resumo
Systemic polymyxin B, neomycin and bacitracin are nephrotoxic, and cidofovir causes dose-limiting proximal tubular kidney injury. Combined exposure may cause severe renal damage, and cidofovir labeling contraindicates concurrent nephrotoxic agents. Risk applies mainly to systemic or heavily absorbed use rather than small topical applications.
O que esta interação significa em palavras simples
Bacitracin-neomycin-polymyxin and Cidofovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bacitracin-neomycin-polymyxin belongs to Anti Bacterial; Cidofovir belongs to Anti Virals.
Por que acontece
Additive nephrotoxicity through direct renal tubular injury by both agents.
O que fazer
Avoid systemic or heavily absorbed use of these antibiotics during and shortly after cidofovir therapy. If unavoidable, monitor serum creatinine and urine protein closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Bacitracin-neomycin-polymyxin
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Bacitracin-neomycin-polymyxin Grave
- Atracurium + Bacitracin-neomycin-polymyxin Grave
- Bacitracin-neomycin-polymyxin + Capreomycin Grave
- Bacitracin-neomycin-polymyxin + Cisatracurium Grave
- Bacitracin-neomycin-polymyxin + Pancuronium Grave
- Bacitracin-neomycin-polymyxin + Rocuronium Grave
Outras interações de Cidofovir
- Amikacin + Cidofovir Contraindicada
- Amphotericin b deoxycholate + Cidofovir Contraindicada
- Amphotericin b + Cidofovir Contraindicada
- Bacitracin + Cidofovir Contraindicada
- Capreomycin + Cidofovir Contraindicada
- Cephaloridine + Cidofovir Contraindicada
Perguntas frequentes
Can I take Bacitracin-neomycin-polymyxin with Cidofovir?
MediHelp rates the interaction as major. Bacitracin-neomycin-polymyxin and Cidofovir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Systemic polymyxin B, neomycin and bacitracin are nephrotoxic, and cidofovir causes dose-limiting proximal tubular kidney injury. Combined exposure may cause severe renal damage, and cidofovir labeling contraindicates concurrent nephrotoxic agents. Risk applies mainly to systemic or heavily absorbed use rather than small topical applications.
How serious is the interaction between Bacitracin-neomycin-polymyxin and Cidofovir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic or heavily absorbed use of these antibiotics during and shortly after cidofovir therapy. If unavoidable, monitor serum creatinine and urine protein closely.
What other medicines interact with Bacitracin-neomycin-polymyxin?
MediHelp also lists interactions of Bacitracin-neomycin-polymyxin with, for example, Allogeneic cultured keratinocytes / fibroblasts in bovine collagen, Atracurium, Capreomycin. The full list is on the Bacitracin-neomycin-polymyxin page.
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