Interações medicamentosas
Bacitracin-neomycin-polymyxin + Pancuronium
Gravidade: Grave
Bacitracin-neomycin-polymyxin and Pancuronium: major interaction.
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Resumo
Polymyxin B and neomycin can add to the neuromuscular blockade of pancuronium. This may prolong paralysis and cause respiratory depression or delayed recovery. The risk is mainly with systemic or irrigation use, not small topical areas.
O que esta interação significa em palavras simples
Bacitracin-neomycin-polymyxin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bacitracin-neomycin-polymyxin belongs to Anti Bacterial; Pancuronium belongs to Musculoskeletal.
Por que acontece
Additive pharmacodynamic neuromuscular blockade through reduced presynaptic acetylcholine release and postsynaptic receptor effects.
O que fazer
Avoid systemic, irrigation or large-area combination antibiotic exposure during neuromuscular blockade where possible. If used, monitor neuromuscular function with train-of-four and ensure ventilatory support is available.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Bacitracin-neomycin-polymyxin
- Allogeneic cultured keratinocytes / fibroblasts in bovine collagen + Bacitracin-neomycin-polymyxin Grave
- Atracurium + Bacitracin-neomycin-polymyxin Grave
- Bacitracin-neomycin-polymyxin + Capreomycin Grave
- Bacitracin-neomycin-polymyxin + Cidofovir Grave
- Bacitracin-neomycin-polymyxin + Cisatracurium Grave
- Bacitracin-neomycin-polymyxin + Rocuronium Grave
Outras interações de Pancuronium
Perguntas frequentes
Can I take Bacitracin-neomycin-polymyxin with Pancuronium?
MediHelp rates the interaction as major. Bacitracin-neomycin-polymyxin and Pancuronium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Polymyxin B and neomycin can add to the neuromuscular blockade of pancuronium. This may prolong paralysis and cause respiratory depression or delayed recovery. The risk is mainly with systemic or irrigation use, not small topical areas.
How serious is the interaction between Bacitracin-neomycin-polymyxin and Pancuronium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid systemic, irrigation or large-area combination antibiotic exposure during neuromuscular blockade where possible. If used, monitor neuromuscular function with train-of-four and ensure ventilatory support is available.
What other medicines interact with Bacitracin-neomycin-polymyxin?
MediHelp also lists interactions of Bacitracin-neomycin-polymyxin with, for example, Allogeneic cultured keratinocytes / fibroblasts in bovine collagen, Atracurium, Capreomycin. The full list is on the Bacitracin-neomycin-polymyxin page.
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