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Interações medicamentosas

Baricitinib + Bcg vaccine live

Gravidade: Contraindicada

Baricitinib and Bcg vaccine live: contraindicated interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Baricitinib-related immunosuppression raises the risk of disseminated BCG infection from the live vaccine and may reduce its effectiveness.

O que esta interação significa em palavras simples

Baricitinib and Bcg vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Nível de evidência: Moderate

Por que acontece

JAK inhibition-induced immunosuppression allows uncontrolled replication of live attenuated bacteria.

O que fazer

Do not give BCG vaccine during baricitinib treatment. Vaccinate before starting therapy where indicated, following current guidelines.

O que perguntar ao farmacêutico

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

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Perguntas frequentes

Can I take Baricitinib with Bcg vaccine live?

MediHelp rates the interaction as contraindicated. Baricitinib and Bcg vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Baricitinib-related immunosuppression raises the risk of disseminated BCG infection from the live vaccine and may reduce its effectiveness.

How serious is the interaction between Baricitinib and Bcg vaccine live?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give BCG vaccine during baricitinib treatment. Vaccinate before starting therapy where indicated, following current guidelines.

What other medicines interact with Baricitinib?

MediHelp also lists interactions of Baricitinib with, for example, Adenovirus types 4 and 7 live, Tofacitinib, Upadacitinib. The full list is on the Baricitinib page.

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