Interações medicamentosas
Belladonna and opium + Brompheniramine
Gravidade: Grave
Belladonna and opium and Brompheniramine: major interaction.
Última atualização Fontes: US FDA label
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Opium causes sedation and respiratory depression, and belladonna adds anticholinergic effects. Brompheniramine adds both sedative and anticholinergic burden, raising the risks of oversedation, constipation, urinary retention and confusion.
O que esta interação significa em palavras simples
Belladonna and opium and Brompheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive CNS and respiratory depression from opioid agonism and H1 antagonism, plus additive anticholinergic effects.
O que fazer
Use the lowest effective doses and monitor sedation, respiratory rate and bowel and bladder function. Avoid in patients at risk of respiratory depression.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Brompheniramine
Perguntas frequentes
Can I take Belladonna and opium with Brompheniramine?
MediHelp rates the interaction as major. Belladonna and opium and Brompheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opium causes sedation and respiratory depression, and belladonna adds anticholinergic effects. Brompheniramine adds both sedative and anticholinergic burden, raising the risks of oversedation, constipation, urinary retention and confusion.
How serious is the interaction between Belladonna and opium and Brompheniramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, respiratory rate and bowel and bladder function. Avoid in patients at risk of respiratory depression.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Benzhydrocodone / acetaminophen, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Brompheniramine page.
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