Interações medicamentosas
Benzhydrocodone / acetaminophen + Brompheniramine
Gravidade: Grave
Benzhydrocodone / acetaminophen and Brompheniramine: major interaction.
Última atualização Fontes: US FDA label
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Resumo
Benzhydrocodone is an opioid prodrug of hydrocodone, and brompheniramine can add to sedation and respiratory depression. Opioid labeling warns about combining with other CNS depressants.
O que esta interação significa em palavras simples
Benzhydrocodone / acetaminophen and Brompheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive CNS and respiratory depression from opioid agonism and H1 antagonism.
O que fazer
Use the lowest effective doses and monitor sedation and respiratory rate. Prefer a non-sedating antihistamine where possible.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Brompheniramine
Perguntas frequentes
Can I take Benzhydrocodone / acetaminophen with Brompheniramine?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Brompheniramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzhydrocodone is an opioid prodrug of hydrocodone, and brompheniramine can add to sedation and respiratory depression. Opioid labeling warns about combining with other CNS depressants.
How serious is the interaction between Benzhydrocodone / acetaminophen and Brompheniramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory rate. Prefer a non-sedating antihistamine where possible.
What other medicines interact with Brompheniramine?
MediHelp also lists interactions of Brompheniramine with, for example, Alfentanil, Belladonna and opium, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Brompheniramine page.
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