Interações medicamentosas
Benazepril + Candesartan-hydrochlorothiazide
Gravidade: Grave
Benazepril and Candesartan-hydrochlorothiazide: major interaction.
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Resumo
Benazepril added to candesartan produces dual renin-angiotensin system blockade. This increases the risk of hypotension, hyperkalemia and renal impairment without added benefit in most patients.
O que esta interação significa em palavras simples
Benazepril and Candesartan-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Benazepril belongs to Cardiovascular; Candesartan-hydrochlorothiazide belongs to Cardiovascular.
Por que acontece
Additive pharmacodynamic inhibition of the renin-angiotensin-aldosterone system by an ACE inhibitor and an angiotensin receptor blocker.
O que fazer
Avoid the combination and use one renin-angiotensin agent. If unavoidable, monitor potassium, creatinine and blood pressure closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicada
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicada
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicada
- Acemetacin + Candesartan-hydrochlorothiazide Grave
- Amifostine + Candesartan-hydrochlorothiazide Grave
- Amiloride + Candesartan-hydrochlorothiazide Grave
Outras interações de Benazepril
- Aliskiren + Benazepril Contraindicada
- Benazepril + Sacubitril / valsartan Contraindicada
- Benazepril + Sacubitril-valsartan Contraindicada
- Amifostine + Benazepril Grave
- Amiloride + Benazepril Grave
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Grave
Perguntas frequentes
Can I take Benazepril with Candesartan-hydrochlorothiazide?
MediHelp rates the interaction as major. Benazepril and Candesartan-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benazepril added to candesartan produces dual renin-angiotensin system blockade. This increases the risk of hypotension, hyperkalemia and renal impairment without added benefit in most patients.
How serious is the interaction between Benazepril and Candesartan-hydrochlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use one renin-angiotensin agent. If unavoidable, monitor potassium, creatinine and blood pressure closely.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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