Interações medicamentosas
Amlodipine-hydrochlorothiazide-valsartan + Benazepril
Gravidade: Grave
Amlodipine-hydrochlorothiazide-valsartan and Benazepril: major interaction.
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Resumo
Adding an ACE inhibitor to a regimen already containing the angiotensin receptor blocker valsartan produces dual renin-angiotensin system blockade. This raises the risk of symptomatic hypotension, hyperkalemia and acute kidney injury without a meaningful cardiovascular benefit in most patients.
O que esta interação significa em palavras simples
Amlodipine-hydrochlorothiazide-valsartan and Benazepril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-hydrochlorothiazide-valsartan belongs to Cardiovascular; Benazepril belongs to Cardiovascular.
Por que acontece
Additive pharmacodynamic inhibition of the renin-angiotensin-aldosterone system at two different points, reducing glomerular filtration pressure and aldosterone-mediated potassium excretion.
O que fazer
Avoid the combination and use a single renin-angiotensin agent. If it is unavoidable, monitor blood pressure, serum potassium and creatinine closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Amlodipine-hydrochlorothiazide-valsartan
- Aliskiren + Amlodipine-hydrochlorothiazide-valsartan Contraindicada
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicada
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicada
- Aceclofenac + Amlodipine-hydrochlorothiazide-valsartan Grave
- Aldesleukin + Amlodipine-hydrochlorothiazide-valsartan Grave
- Amifostine + Amlodipine-hydrochlorothiazide-valsartan Grave
Outras interações de Benazepril
- Aliskiren + Benazepril Contraindicada
- Benazepril + Sacubitril / valsartan Contraindicada
- Benazepril + Sacubitril-valsartan Contraindicada
- Amifostine + Benazepril Grave
- Amiloride + Benazepril Grave
- Amlodipine-olmesartan-hydrochlorothiazide + Benazepril Grave
Perguntas frequentes
Can I take Amlodipine-hydrochlorothiazide-valsartan with Benazepril?
MediHelp rates the interaction as major. Amlodipine-hydrochlorothiazide-valsartan and Benazepril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Adding an ACE inhibitor to a regimen already containing the angiotensin receptor blocker valsartan produces dual renin-angiotensin system blockade. This raises the risk of symptomatic hypotension, hyperkalemia and acute kidney injury without a meaningful cardiovascular benefit in most patients.
How serious is the interaction between Amlodipine-hydrochlorothiazide-valsartan and Benazepril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a single renin-angiotensin agent. If it is unavoidable, monitor blood pressure, serum potassium and creatinine closely.
What other medicines interact with Amlodipine-hydrochlorothiazide-valsartan?
MediHelp also lists interactions of Amlodipine-hydrochlorothiazide-valsartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-hydrochlorothiazide-valsartan page.
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