Interações medicamentosas
Benazepril + Sacubitril / valsartan
Gravidade: Contraindicada
Benazepril and Sacubitril / valsartan: contraindicated interaction.
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Resumo
Sacubitril inhibits neprilysin, which degrades bradykinin, and ACE inhibitors block another bradykinin-degrading pathway. Together they markedly raise the risk of angioedema, which can be life-threatening. Valsartan also adds dual renin-angiotensin blockade.
O que esta interação significa em palavras simples
Benazepril and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Combined inhibition of neprilysin and ACE causes bradykinin accumulation, with added renin-angiotensin blockade from valsartan.
O que fazer
Never co-administer. Allow a washout of at least 36 hours when switching between an ACE inhibitor and sacubitril/valsartan in either direction.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Benazepril
- Aliskiren + Benazepril Contraindicada
- Benazepril + Sacubitril-valsartan Contraindicada
- Amifostine + Benazepril Grave
- Amiloride + Benazepril Grave
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Grave
- Amlodipine-olmesartan-hydrochlorothiazide + Benazepril Grave
Perguntas frequentes
Can I take Benazepril with Sacubitril / valsartan?
MediHelp rates the interaction as contraindicated. Benazepril and Sacubitril / valsartan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Sacubitril inhibits neprilysin, which degrades bradykinin, and ACE inhibitors block another bradykinin-degrading pathway. Together they markedly raise the risk of angioedema, which can be life-threatening. Valsartan also adds dual renin-angiotensin blockade.
How serious is the interaction between Benazepril and Sacubitril / valsartan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Never co-administer. Allow a washout of at least 36 hours when switching between an ACE inhibitor and sacubitril/valsartan in either direction.
What other medicines interact with Benazepril?
MediHelp also lists interactions of Benazepril with, for example, Aliskiren, Sacubitril-valsartan, Amifostine. The full list is on the Benazepril page.
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