Interações medicamentosas
Benztropine + Memantine-donepezil
Gravidade: Grave
Benztropine and Memantine-donepezil: major interaction.
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Resumo
Benztropine is a strongly anticholinergic drug that opposes donepezil's cholinergic effect, and it can worsen confusion and memory in dementia. Donepezil may in turn reduce benztropine's control of parkinsonism.
O que esta interação significa em palavras simples
Benztropine and Memantine-donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Benztropine belongs to Central Nervous System; Memantine-donepezil belongs to Central Nervous System.
Por que acontece
Pharmacodynamic antagonism between a muscarinic antagonist and a cholinesterase inhibitor.
O que fazer
Avoid anticholinergic antiparkinson agents in dementia where possible and consider alternative treatment for extrapyramidal symptoms. If used, monitor cognition.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicada
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- Amantadine + Memantine-donepezil Grave
- Amiodarone + Memantine-donepezil Grave
- Amisulpride + Memantine-donepezil Grave
- Amitriptyline + Memantine-donepezil Grave
Outras interações de Benztropine
- Abobotulinumtoxina + Benztropine Moderada
- Amantadine + Benztropine Moderada
- Amitriptyline + Benztropine Moderada
- Amoxapine + Benztropine Moderada
- Atropine iv / + Benztropine Moderada
- Atropine + Benztropine Moderada
Perguntas frequentes
Can I take Benztropine with Memantine-donepezil?
MediHelp rates the interaction as major. Benztropine and Memantine-donepezil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benztropine is a strongly anticholinergic drug that opposes donepezil's cholinergic effect, and it can worsen confusion and memory in dementia. Donepezil may in turn reduce benztropine's control of parkinsonism.
How serious is the interaction between Benztropine and Memantine-donepezil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid anticholinergic antiparkinson agents in dementia where possible and consider alternative treatment for extrapyramidal symptoms. If used, monitor cognition.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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