Interações medicamentosas
Berotralstat + Thioridazine
Gravidade: Grave
Berotralstat and Thioridazine: major interaction.
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Resumo
Berotralstat inhibits CYP2D6 and may raise thioridazine concentrations. Because thioridazine is a narrow-therapeutic-index drug that prolongs QT, higher levels can raise the risk of serious arrhythmia.
O que esta interação significa em palavras simples
Berotralstat and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Berotralstat belongs to Miscellaneous; Thioridazine belongs to Central Nervous System.
Por que acontece
Inhibition of CYP2D6-mediated metabolism of thioridazine.
O que fazer
Avoid the combination if possible; otherwise reduce thioridazine dose and monitor ECG and QTc.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Thioridazine
- Abiraterone + Thioridazine Contraindicada
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- Amiodarone + Thioridazine Contraindicada
- Amisulpride + Thioridazine Contraindicada
- Amitriptyline + Thioridazine Contraindicada
- Amoxapine + Thioridazine Contraindicada
Outras interações de Berotralstat
- Berotralstat + Ergotamine Grave
- Berotralstat + Nilotinib Grave
- Berotralstat + Pimozide Grave
- Berotralstat + Quinidine Grave
- Berotralstat + Quinine Grave
- Berotralstat + Tacrolimus Grave
Perguntas frequentes
Can I take Berotralstat with Thioridazine?
MediHelp rates the interaction as major. Berotralstat and Thioridazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Berotralstat inhibits CYP2D6 and may raise thioridazine concentrations. Because thioridazine is a narrow-therapeutic-index drug that prolongs QT, higher levels can raise the risk of serious arrhythmia.
How serious is the interaction between Berotralstat and Thioridazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise reduce thioridazine dose and monitor ECG and QTc.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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