Interações medicamentosas
Bivalirudin + Piperacillin-tazobactam
Gravidade: Moderada
Bivalirudin and Piperacillin-tazobactam: moderate interaction.
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Resumo
Piperacillin can impair platelet function and occasionally cause bleeding, which may add to the anticoagulant effect of bivalirudin. Clinical significance is usually modest. Risk is higher in renal impairment, where both drugs accumulate.
O que esta interação significa em palavras simples
Bivalirudin and Piperacillin-tazobactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Additive bleeding risk from direct thrombin inhibition plus penicillin-induced platelet dysfunction.
O que fazer
Monitor for bleeding and ACT or aPTT during bivalirudin therapy. Adjust bivalirudin dose for renal function.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Piperacillin-tazobactam
Perguntas frequentes
Can I take Bivalirudin with Piperacillin-tazobactam?
MediHelp rates the interaction as moderate. Bivalirudin and Piperacillin-tazobactam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Piperacillin can impair platelet function and occasionally cause bleeding, which may add to the anticoagulant effect of bivalirudin. Clinical significance is usually modest. Risk is higher in renal impairment, where both drugs accumulate.
How serious is the interaction between Bivalirudin and Piperacillin-tazobactam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and ACT or aPTT during bivalirudin therapy. Adjust bivalirudin dose for renal function.
What other medicines interact with Piperacillin-tazobactam?
MediHelp also lists interactions of Piperacillin-tazobactam with, for example, Vancomycin, Amikacin, Antithrombin alfa. The full list is on the Piperacillin-tazobactam page.
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