Interações medicamentosas
Blinatumomab + Cyclosporin
Gravidade: Moderada
Blinatumomab and Cyclosporin: moderate interaction.
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Resumo
Blinatumomab causes a transient cytokine release at treatment initiation and after dose re-starts, which can temporarily suppress CYP450 activity. Cyclosporine is a narrow therapeutic index CYP3A4 substrate, so its blood concentrations may rise and increase the risk of nephrotoxicity and neurotoxicity.
O que esta interação significa em palavras simples
Blinatumomab and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Blinatumomab belongs to Oncology; Cyclosporin belongs to Miscellaneous.
Por que acontece
Cytokine release (e.g., IL-6) transiently downregulates CYP450 enzymes, reducing cyclosporine metabolism.
O que fazer
Monitor cyclosporine trough concentrations and renal function closely during the first days of the first cycle and after re-initiation of blinatumomab. Reduce the cyclosporine dose according to levels and clinical signs of toxicity.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicada
- Aliskiren + Cyclosporin Contraindicada
- Bcg vaccine live + Cyclosporin Contraindicada
- Bosentan + Cyclosporin Contraindicada
- Cidofovir + Cyclosporin Contraindicada
- Cyclosporin + Dengue vaccine Contraindicada
Outras interações de Blinatumomab
- Blinatumomab + Carbamazepine Moderada
- Blinatumomab + Ethosuximide Moderada
- Blinatumomab + Phenytoin Moderada
- Blinatumomab + Quinidine Moderada
- Blinatumomab + Quinine Moderada
- Blinatumomab + Siponimod Moderada
Perguntas frequentes
Can I take Blinatumomab with Cyclosporin?
MediHelp rates the interaction as moderate. Blinatumomab and Cyclosporin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Blinatumomab causes a transient cytokine release at treatment initiation and after dose re-starts, which can temporarily suppress CYP450 activity. Cyclosporine is a narrow therapeutic index CYP3A4 substrate, so its blood concentrations may rise and increase the risk of nephrotoxicity and neurotoxicity.
How serious is the interaction between Blinatumomab and Cyclosporin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough concentrations and renal function closely during the first days of the first cycle and after re-initiation of blinatumomab. Reduce the cyclosporine dose according to levels and clinical signs of toxicity.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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