Interações medicamentosas
Bosutinib + Clarithromycin
Gravidade: Grave
Bosutinib and Clarithromycin: major interaction.
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Resumo
Clarithromycin markedly raises bosutinib concentrations by inhibiting its CYP3A4 metabolism and P-glycoprotein efflux. This can cause hepatotoxicity, diarrhea, myelosuppression and QT effects.
O que esta interação significa em palavras simples
Bosutinib and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bosutinib belongs to Oncology; Clarithromycin belongs to Anti Bacterial.
Por que acontece
Inhibition of CYP3A4 and P-glycoprotein reduces bosutinib clearance.
O que fazer
Avoid the combination and use an alternative antibiotic like azithromycin. If unavoidable, monitor closely for toxicity and consider bosutinib dose reduction per labeling.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Clarithromycin
- Astemizole + Clarithromycin Contraindicada
- Avanafil + Clarithromycin Contraindicada
- Cisapride + Clarithromycin Contraindicada
- Clarithromycin + Colchicine Contraindicada
- Clarithromycin + Conivaptan Contraindicada
- Clarithromycin + Dihydroergotamine Contraindicada
Outras interações de Bosutinib
- Amiodarone + Bosutinib Grave
- Apalutamide + Bosutinib Grave
- Aprepitant + Bosutinib Grave
- Bosentan + Bosutinib Grave
- Bosutinib + Carbamazepine Grave
- Bosutinib + Chlorpromazine Grave
Perguntas frequentes
Can I take Bosutinib with Clarithromycin?
MediHelp rates the interaction as major. Bosutinib and Clarithromycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Clarithromycin markedly raises bosutinib concentrations by inhibiting its CYP3A4 metabolism and P-glycoprotein efflux. This can cause hepatotoxicity, diarrhea, myelosuppression and QT effects.
How serious is the interaction between Bosutinib and Clarithromycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative antibiotic like azithromycin. If unavoidable, monitor closely for toxicity and consider bosutinib dose reduction per labeling.
What other medicines interact with Clarithromycin?
MediHelp also lists interactions of Clarithromycin with, for example, Astemizole, Avanafil, Cisapride. The full list is on the Clarithromycin page.
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