Interações medicamentosas
Brentuximab + Dengue vaccine
Gravidade: Grave
Brentuximab and Dengue vaccine: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Brentuximab vedotin is cytotoxic and causes myelosuppression, which can blunt the immune response to vaccination. Dengue vaccine is live attenuated, so replicating vaccine virus could cause disease in an immunocompromised patient.
O que esta interação significa em palavras simples
Brentuximab and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Cytotoxic immunosuppression impairs vaccine response and may permit uncontrolled replication of live attenuated virus.
O que fazer
Avoid live dengue vaccine during brentuximab therapy and until immune recovery is documented. Plan vaccination before treatment where feasible.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Brentuximab
- Bleomycin + Brentuximab Contraindicada
- Brentuximab + Etrasimod Grave
- Brentuximab + Idelalisib Grave
- Brentuximab + Levoketoconazole Grave
- Brentuximab + Nefazodone Grave
- Brentuximab + Ritonavir Grave
Perguntas frequentes
Can I take Brentuximab with Dengue vaccine?
MediHelp rates the interaction as major. Brentuximab and Dengue vaccine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brentuximab vedotin is cytotoxic and causes myelosuppression, which can blunt the immune response to vaccination. Dengue vaccine is live attenuated, so replicating vaccine virus could cause disease in an immunocompromised patient.
How serious is the interaction between Brentuximab and Dengue vaccine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live dengue vaccine during brentuximab therapy and until immune recovery is documented. Plan vaccination before treatment where feasible.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Etrasimod, Idelalisib. The full list is on the Brentuximab page.
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