Interações medicamentosas
Brentuximab + Idelalisib
Gravidade: Grave
Brentuximab and Idelalisib: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Idelalisib is a strong CYP3A inhibitor, and MMAE from brentuximab vedotin is a CYP3A4 substrate. Strong CYP3A4 inhibitors raise MMAE exposure, which may increase neutropenia and other toxicities. Idelalisib itself also carries infection and neutropenia risk.
O que esta interação significa em palavras simples
Brentuximab and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Brentuximab belongs to Oncology; Idelalisib belongs to Oncology.
Por que acontece
Strong CYP3A inhibition by idelalisib reduces MMAE metabolism and increases exposure.
O que fazer
Monitor closely for neutropenia, infection and neuropathy, and consider an alternative to idelalisib. Hold or reduce brentuximab if toxicity occurs.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Brentuximab e Idelalisib, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Brentuximab
- Bleomycin + Brentuximab Contraindicada
- Brentuximab + Dengue vaccine Grave
- Brentuximab + Etrasimod Grave
- Brentuximab + Levoketoconazole Grave
- Brentuximab + Nefazodone Grave
- Brentuximab + Ritonavir Grave
Outras interações de Idelalisib
- Alfuzosin + Idelalisib Contraindicada
- Cisapride + Idelalisib Contraindicada
- Dihydroergotamine + Idelalisib Contraindicada
- Dronedarone + Idelalisib Contraindicada
- Eletriptan + Idelalisib Contraindicada
- Eplerenone + Idelalisib Contraindicada
Perguntas frequentes
Can I take Brentuximab with Idelalisib?
MediHelp rates the interaction as major. Brentuximab and Idelalisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Idelalisib is a strong CYP3A inhibitor, and MMAE from brentuximab vedotin is a CYP3A4 substrate. Strong CYP3A4 inhibitors raise MMAE exposure, which may increase neutropenia and other toxicities. Idelalisib itself also carries infection and neutropenia risk.
How serious is the interaction between Brentuximab and Idelalisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor closely for neutropenia, infection and neuropathy, and consider an alternative to idelalisib. Hold or reduce brentuximab if toxicity occurs.
What other medicines interact with Brentuximab?
MediHelp also lists interactions of Brentuximab with, for example, Bleomycin, Dengue vaccine, Etrasimod. The full list is on the Brentuximab page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
