Interações medicamentosas
Bromocriptine + Darunavir
Gravidade: Grave
Bromocriptine and Darunavir: major interaction.
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Resumo
Darunavir, usually given with a booster such as ritonavir or cobicistat, strongly inhibits CYP3A4 and can raise bromocriptine exposure. Higher levels may cause nausea, hypotension, dizziness, somnolence, hallucinations and other dopaminergic adverse effects.
O que esta interação significa em palavras simples
Bromocriptine and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bromocriptine belongs to Central Nervous System; Darunavir belongs to Anti Virals.
Por que acontece
Inhibition of CYP3A4-mediated metabolism of bromocriptine reduces its clearance.
O que fazer
Avoid the combination where possible; if it is necessary, start bromocriptine at a low dose and titrate slowly while monitoring blood pressure and CNS effects. Reduce the bromocriptine dose if adverse effects appear.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Bromocriptine
Outras interações de Darunavir
- Alfuzosin + Darunavir Contraindicada
- Avanafil + Darunavir Contraindicada
- Darunavir + Dronedarone Contraindicada
- Darunavir + Eletriptan Contraindicada
- Darunavir + Ergotamine Contraindicada
- Darunavir + Flibanserin Contraindicada
Perguntas frequentes
Can I take Bromocriptine with Darunavir?
MediHelp rates the interaction as major. Bromocriptine and Darunavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, usually given with a booster such as ritonavir or cobicistat, strongly inhibits CYP3A4 and can raise bromocriptine exposure. Higher levels may cause nausea, hypotension, dizziness, somnolence, hallucinations and other dopaminergic adverse effects.
How serious is the interaction between Bromocriptine and Darunavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible; if it is necessary, start bromocriptine at a low dose and titrate slowly while monitoring blood pressure and CNS effects. Reduce the bromocriptine dose if adverse effects appear.
What other medicines interact with Bromocriptine?
MediHelp also lists interactions of Bromocriptine with, for example, Amisulpride, Atazanavir, Cobicistat. The full list is on the Bromocriptine page.
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