Interações medicamentosas
Buprenorphine + Eluxadoline
Gravidade: Grave
Buprenorphine and Eluxadoline: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Eluxadoline is a mu-opioid agonist used for diarrhea-predominant IBS and can cause severe constipation and pancreatitis-related events. Adding buprenorphine, which also slows gut transit, increases the risk of serious constipation and related complications.
O que esta interação significa em palavras simples
Buprenorphine and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Buprenorphine belongs to Musculoskeletal; Eluxadoline belongs to Gastrointestinal Tract.
Por que acontece
Additive opioid-receptor mediated reduction in gastrointestinal motility.
O que fazer
Avoid combining where possible; the eluxadoline label advises against use with other drugs that cause constipation. If both are required, monitor bowel function closely and stop eluxadoline if severe constipation develops.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Buprenorphine
- Alvimopan + Buprenorphine Contraindicada
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates Contraindicada
- Buprenorphine + Olanzapine / samidorphan Contraindicada
- Buprenorphine + Phenelzine Contraindicada
- Buprenorphine + Pimozide Contraindicada
- Buprenorphine + Thioridazine Contraindicada
Outras interações de Eluxadoline
Perguntas frequentes
Can I take Buprenorphine with Eluxadoline?
MediHelp rates the interaction as major. Buprenorphine and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eluxadoline is a mu-opioid agonist used for diarrhea-predominant IBS and can cause severe constipation and pancreatitis-related events. Adding buprenorphine, which also slows gut transit, increases the risk of serious constipation and related complications.
How serious is the interaction between Buprenorphine and Eluxadoline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining where possible; the eluxadoline label advises against use with other drugs that cause constipation. If both are required, monitor bowel function closely and stop eluxadoline if severe constipation develops.
What other medicines interact with Buprenorphine?
MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.
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