Interações medicamentosas
Diphenoxylate-atropine + Eluxadoline
Gravidade: Grave
Diphenoxylate-atropine and Eluxadoline: major interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Eluxadoline is an opioid receptor modulator whose labeling warns against use with drugs that cause constipation. Diphenoxylate-atropine is strongly constipating and increases the risk of serious complications such as ileus or obstruction.
O que esta interação significa em palavras simples
Diphenoxylate-atropine and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Diphenoxylate-atropine belongs to Gastrointestinal Tract; Eluxadoline belongs to Gastrointestinal Tract.
Por que acontece
Additive inhibition of gastrointestinal motility via opioid and anticholinergic effects.
O que fazer
Avoid using the two together. If constipation or abdominal pain develops, stop the agents and assess for ileus.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Diphenoxylate-atropine
- Diphenoxylate-atropine + Isocarboxazid Contraindicada
- Diphenoxylate-atropine + Phenelzine Contraindicada
- Diphenoxylate-atropine + Tranylcypromine Contraindicada
- Alfentanil + Diphenoxylate-atropine Grave
- Alvimopan + Diphenoxylate-atropine Grave
- Amitriptyline + Diphenoxylate-atropine Grave
Outras interações de Eluxadoline
Perguntas frequentes
Can I take Diphenoxylate-atropine with Eluxadoline?
MediHelp rates the interaction as major. Diphenoxylate-atropine and Eluxadoline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eluxadoline is an opioid receptor modulator whose labeling warns against use with drugs that cause constipation. Diphenoxylate-atropine is strongly constipating and increases the risk of serious complications such as ileus or obstruction.
How serious is the interaction between Diphenoxylate-atropine and Eluxadoline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using the two together. If constipation or abdominal pain develops, stop the agents and assess for ileus.
What other medicines interact with Diphenoxylate-atropine?
MediHelp also lists interactions of Diphenoxylate-atropine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Diphenoxylate-atropine page.
Monografias completas, posologia e verificador de interações no app MediHelp
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