Interações medicamentosas
Eluxadoline + Hydromorphone
Gravidade: Grave
Eluxadoline and Hydromorphone: major interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Eluxadoline acts on opioid receptors in the gut and can cause constipation and, rarely, pancreatitis or sphincter of Oddi spasm. Hydromorphone also slows gut motility, so combined use raises the risk of severe constipation and related complications.
O que esta interação significa em palavras simples
Eluxadoline and Hydromorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eluxadoline belongs to Gastrointestinal Tract; Hydromorphone belongs to Musculoskeletal.
Por que acontece
Additive inhibition of gastrointestinal motility via opioid receptor activity.
O que fazer
Avoid the combination if possible; if used, monitor bowel function closely and stop eluxadoline if severe constipation develops. Use a laxative regimen appropriately for the opioid.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Eluxadoline e Hydromorphone, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Hydromorphone
- Alvimopan + Hydromorphone Contraindicada
- Bupropion-naltrexone + Hydromorphone Contraindicada
- Hydromorphone + Isocarboxazid Contraindicada
- Hydromorphone + Olanzapine / samidorphan Contraindicada
- Hydromorphone + Phenelzine Contraindicada
- Hydromorphone + Tranylcypromine Contraindicada
Outras interações de Eluxadoline
Perguntas frequentes
Can I take Eluxadoline with Hydromorphone?
MediHelp rates the interaction as major. Eluxadoline and Hydromorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eluxadoline acts on opioid receptors in the gut and can cause constipation and, rarely, pancreatitis or sphincter of Oddi spasm. Hydromorphone also slows gut motility, so combined use raises the risk of severe constipation and related complications.
How serious is the interaction between Eluxadoline and Hydromorphone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; if used, monitor bowel function closely and stop eluxadoline if severe constipation develops. Use a laxative regimen appropriately for the opioid.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
