Drug interactions
Buprenorphine long-acting + Dantrolene
Severity: Major
Buprenorphine long-acting and Dantrolene: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene causes drowsiness and muscle weakness, and long-acting injectable buprenorphine adds sustained opioid sedation and respiratory depression. Because the injection cannot be withdrawn, the effect can last a long time.
What this interaction means in plain words
Buprenorphine long-acting and Dantrolene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive central nervous system and respiratory depression from buprenorphine with dantrolene's sedation and muscle weakness.
What to do
Use together only when alternatives are inadequate, and monitor for sedation and respiratory depression. Reduce dantrolene dose if excessive drowsiness occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Buprenorphine long-acting and Dantrolene, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dantrolene
Frequently asked questions
Can I take Buprenorphine long-acting with Dantrolene?
MediHelp rates the interaction as major. Buprenorphine long-acting and Dantrolene can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dantrolene causes drowsiness and muscle weakness, and long-acting injectable buprenorphine adds sustained opioid sedation and respiratory depression. Because the injection cannot be withdrawn, the effect can last a long time.
How serious is the interaction between Buprenorphine long-acting and Dantrolene?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only when alternatives are inadequate, and monitor for sedation and respiratory depression. Reduce dantrolene dose if excessive drowsiness occurs.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine subdermal implant, Buprenorphine transdermal. The full list is on the Dantrolene page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
