Interações medicamentosas
Buprenorphine long-acting + Phenelzine
Gravidade: Contraindicada
Buprenorphine long-acting and Phenelzine: contraindicated interaction.
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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Combining an MAO inhibitor with buprenorphine may cause serotonin syndrome or opioid toxicity, including respiratory depression and coma. Long-acting injectable buprenorphine cannot be quickly withdrawn, which prolongs exposure if a reaction occurs. Labeling advises against use during or within 14 days of MAOI therapy.
O que esta interação significa em palavras simples
Buprenorphine long-acting and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Additive serotonergic effects and potentiation of opioid CNS and respiratory depression, possibly through altered opioid metabolism, in the setting of MAO inhibition.
O que fazer
Do not start long-acting buprenorphine within 14 days of stopping phenelzine or while it is being taken. Choose a non-serotonergic alternative or allow an adequate washout.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Phenelzine
- 5-HTP + Phenelzine Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amoxapine + Phenelzine Contraindicada
- Atomoxetine + Phenelzine Contraindicada
- Benzphetamine + Phenelzine Contraindicada
- Brimonidine + Phenelzine Contraindicada
Perguntas frequentes
Can I take Buprenorphine long-acting with Phenelzine?
MediHelp rates the interaction as contraindicated. Buprenorphine long-acting and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an MAO inhibitor with buprenorphine may cause serotonin syndrome or opioid toxicity, including respiratory depression and coma. Long-acting injectable buprenorphine cannot be quickly withdrawn, which prolongs exposure if a reaction occurs. Labeling advises against use during or within 14 days of MAOI therapy.
How serious is the interaction between Buprenorphine long-acting and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not start long-acting buprenorphine within 14 days of stopping phenelzine or while it is being taken. Choose a non-serotonergic alternative or allow an adequate washout.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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