Interações medicamentosas
Brimonidine + Phenelzine
Gravidade: Contraindicada
Brimonidine and Phenelzine: contraindicated interaction.
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Resumo
Brimonidine labelling forbids use with MAO inhibitors, and phenelzine is an irreversible non-selective MAO inhibitor. Systemic absorption of the alpha-2 agonist could lead to unpredictable blood-pressure changes, and the effect on catecholamine handling is poorly characterised.
O que esta interação significa em palavras simples
Brimonidine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Brimonidine belongs to Miscellaneous; Phenelzine belongs to Central Nervous System.
Por que acontece
Uncertain: MAO inhibition may alter handling of circulating amines and potentiate systemic alpha-2 agonist cardiovascular effects
O que fazer
Avoid brimonidine in patients taking phenelzine; use a different intraocular-pressure-lowering agent such as a prostaglandin analogue or beta-blocker where appropriate.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Phenelzine
- 5-HTP + Phenelzine Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amoxapine + Phenelzine Contraindicada
- Atomoxetine + Phenelzine Contraindicada
- Benzphetamine + Phenelzine Contraindicada
- Buprenorphine long-acting + Phenelzine Contraindicada
Outras interações de Brimonidine
- Brimonidine + Isocarboxazid Contraindicada
- Brimonidine + Linezolid Contraindicada
- Brimonidine + Procarbazine Contraindicada
- Brimonidine + Rasagiline Contraindicada
- Brimonidine + Selegiline Contraindicada
- Brimonidine + Tranylcypromine Contraindicada
Perguntas frequentes
Can I take Brimonidine with Phenelzine?
MediHelp rates the interaction as contraindicated. Brimonidine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Brimonidine labelling forbids use with MAO inhibitors, and phenelzine is an irreversible non-selective MAO inhibitor. Systemic absorption of the alpha-2 agonist could lead to unpredictable blood-pressure changes, and the effect on catecholamine handling is poorly characterised.
How serious is the interaction between Brimonidine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid brimonidine in patients taking phenelzine; use a different intraocular-pressure-lowering agent such as a prostaglandin analogue or beta-blocker where appropriate.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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