Interações medicamentosas
Buprenorphine subdermal implant + Chlordiazepoxide-clidinium
Gravidade: Grave
Buprenorphine subdermal implant and Chlordiazepoxide-clidinium: major interaction.
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Resumo
Buprenorphine with benzodiazepines such as chlordiazepoxide can cause profound sedation, respiratory depression, coma and death. The implant gives continuous exposure that cannot be quickly withdrawn.
O que esta interação significa em palavras simples
Buprenorphine subdermal implant and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Por que acontece
Additive CNS and respiratory depression from opioid and benzodiazepine effects.
O que fazer
Use together only when alternatives are inadequate, and keep benzodiazepine dose and duration minimal. Monitor for sedation and respiratory depression.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Chlordiazepoxide-clidinium
- Alfentanil + Chlordiazepoxide-clidinium Grave
- Alprazolam + Chlordiazepoxide-clidinium Grave
- Amobarbital + Chlordiazepoxide-clidinium Grave
- Belladonna and opium + Chlordiazepoxide-clidinium Grave
- Benzhydrocodone / acetaminophen + Chlordiazepoxide-clidinium Grave
- Brexanolone + Chlordiazepoxide-clidinium Grave
Perguntas frequentes
Can I take Buprenorphine subdermal implant with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as major. Buprenorphine subdermal implant and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Buprenorphine with benzodiazepines such as chlordiazepoxide can cause profound sedation, respiratory depression, coma and death. The implant gives continuous exposure that cannot be quickly withdrawn.
How serious is the interaction between Buprenorphine subdermal implant and Chlordiazepoxide-clidinium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together only when alternatives are inadequate, and keep benzodiazepine dose and duration minimal. Monitor for sedation and respiratory depression.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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