Interações medicamentosas
Bupropion-naltrexone + Hydrocodone
Gravidade: Contraindicada
Bupropion-naltrexone and Hydrocodone: contraindicated interaction.
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Resumo
Naltrexone is an opioid antagonist and blocks the analgesic effect of hydrocodone, and can precipitate withdrawal in opioid-dependent patients. Bupropion also inhibits CYP2D6 and may reduce conversion of hydrocodone to hydromorphone, and the combination carries seizure and serotonergic concerns.
O que esta interação significa em palavras simples
Bupropion-naltrexone and Hydrocodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bupropion-naltrexone belongs to Miscellaneous; Hydrocodone belongs to Musculoskeletal.
Por que acontece
Naltrexone competitively antagonizes opioid receptors; bupropion inhibits CYP2D6 and lowers seizure threshold.
O que fazer
Avoid combining; the bupropion-naltrexone product is contraindicated with chronic opioid use. Allow an opioid-free interval of 7 to 10 days before starting it.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Bupropion-naltrexone
- Bupropion-naltrexone + Hydromorphone Contraindicada
- Bupropion-naltrexone + Isocarboxazid Contraindicada
- Bupropion-naltrexone + Linezolid Contraindicada
- Bupropion-naltrexone + Phenelzine Contraindicada
- Bupropion-naltrexone + Rasagiline Contraindicada
- Bupropion-naltrexone + Selegiline Contraindicada
Outras interações de Hydrocodone
- Alvimopan + Hydrocodone Contraindicada
- Hydrocodone + Isocarboxazid Contraindicada
- Hydrocodone + Olanzapine / samidorphan Contraindicada
- Hydrocodone + Phenelzine Contraindicada
- Alfentanil + Hydrocodone Grave
- Alprazolam + Hydrocodone Grave
Perguntas frequentes
Can I take Bupropion-naltrexone with Hydrocodone?
MediHelp rates the interaction as contraindicated. Bupropion-naltrexone and Hydrocodone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Naltrexone is an opioid antagonist and blocks the analgesic effect of hydrocodone, and can precipitate withdrawal in opioid-dependent patients. Bupropion also inhibits CYP2D6 and may reduce conversion of hydrocodone to hydromorphone, and the combination carries seizure and serotonergic concerns.
How serious is the interaction between Bupropion-naltrexone and Hydrocodone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining; the bupropion-naltrexone product is contraindicated with chronic opioid use. Allow an opioid-free interval of 7 to 10 days before starting it.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydromorphone, Isocarboxazid, Linezolid. The full list is on the Bupropion-naltrexone page.
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