Interações medicamentosas
Bupropion-naltrexone + Phenelzine
Gravidade: Contraindicada
Bupropion-naltrexone and Phenelzine: contraindicated interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
O conteúdo clínico desta página está disponível apenas em inglês.
Resumo
Phenelzine (an irreversible non-selective MAO inhibitor) slows catecholamine breakdown, while bupropion blocks reuptake of dopamine and noradrenaline. The combination can produce hypertensive crisis, agitation and seizures; labelling for bupropion prohibits concurrent MAOI therapy.
O que esta interação significa em palavras simples
Bupropion-naltrexone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Bupropion-naltrexone belongs to Miscellaneous; Phenelzine belongs to Central Nervous System.
Por que acontece
MAO inhibition combined with dopamine and noradrenaline reuptake inhibition causes excess catecholamine activity
O que fazer
Do not use together. Wait at least 14 days after stopping phenelzine before starting the other drug; allow at least a week after stopping bupropion before starting an MAOI.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Para assinantes do Pro+
Desbloqueie a página completa
Crie uma conta e comece um teste do Pro+ para desbloquear a orientação completa de conduta para Bupropion-naltrexone e Phenelzine, as notas adicionais, os detalhes da evidência e o verificador de interações para uma prescrição completa.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Experimente o Pro+ grátis por 14 dias na web. Sem cartão.
Outras interações de Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicada
- Bupropion-naltrexone + Hydromorphone Contraindicada
- Bupropion-naltrexone + Isocarboxazid Contraindicada
- Bupropion-naltrexone + Linezolid Contraindicada
- Bupropion-naltrexone + Rasagiline Contraindicada
- Bupropion-naltrexone + Selegiline Contraindicada
Outras interações de Phenelzine
- 5-HTP + Phenelzine Contraindicada
- Amitriptyline + Phenelzine Contraindicada
- Amoxapine + Phenelzine Contraindicada
- Atomoxetine + Phenelzine Contraindicada
- Benzphetamine + Phenelzine Contraindicada
- Brimonidine + Phenelzine Contraindicada
Perguntas frequentes
Can I take Bupropion-naltrexone with Phenelzine?
MediHelp rates the interaction as contraindicated. Bupropion-naltrexone and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenelzine (an irreversible non-selective MAO inhibitor) slows catecholamine breakdown, while bupropion blocks reuptake of dopamine and noradrenaline. The combination can produce hypertensive crisis, agitation and seizures; labelling for bupropion prohibits concurrent MAOI therapy.
How serious is the interaction between Bupropion-naltrexone and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use together. Wait at least 14 days after stopping phenelzine before starting the other drug; allow at least a week after stopping bupropion before starting an MAOI.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
Monografias completas, posologia e verificador de interações no app MediHelp
Abra a referência completa, verifique interações entre vários medicamentos e use as ferramentas de posologia no app MediHelp.
