Interações medicamentosas
Butalbital + Dronabinol
Gravidade: Moderada
Butalbital and Dronabinol: moderate interaction.
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Resumo
Butalbital is a barbiturate that can induce hepatic enzymes, so dronabinol exposure may fall and its effect may weaken. Both agents also depress the CNS, so additive drowsiness and impaired psychomotor function can occur.
O que esta interação significa em palavras simples
Butalbital and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Por que acontece
Barbiturate enzyme induction of CYP3A4/CYP2C9 and additive CNS depression.
O que fazer
Monitor dronabinol response and sedation, and adjust the dronabinol dose accordingly. Advise patients to avoid driving if drowsy.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Dronabinol
- Cefotetan + Dronabinol Contraindicada
- Disulfiram + Dronabinol Contraindicada
- Dronabinol + Midazolam intranasal Grave
- Dronabinol + Zuranolone Grave
- Amobarbital + Dronabinol Moderada
- Apalutamide + Dronabinol Moderada
Perguntas frequentes
Can I take Butalbital with Dronabinol?
MediHelp rates the interaction as moderate. Butalbital and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that can induce hepatic enzymes, so dronabinol exposure may fall and its effect may weaken. Both agents also depress the CNS, so additive drowsiness and impaired psychomotor function can occur.
How serious is the interaction between Butalbital and Dronabinol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor dronabinol response and sedation, and adjust the dronabinol dose accordingly. Advise patients to avoid driving if drowsy.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Disulfiram, Midazolam intranasal. The full list is on the Dronabinol page.
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