Drug interactions
Butalbital + Dronabinol
Severity: Moderate
Butalbital and Dronabinol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that can induce hepatic enzymes, so dronabinol exposure may fall and its effect may weaken. Both agents also depress the CNS, so additive drowsiness and impaired psychomotor function can occur.
What this interaction means in plain words
Butalbital and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate enzyme induction of CYP3A4/CYP2C9 and additive CNS depression.
What to do
Monitor dronabinol response and sedation, and adjust the dronabinol dose accordingly. Advise patients to avoid driving if drowsy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Butalbital with Dronabinol?
MediHelp rates the interaction as moderate. Butalbital and Dronabinol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that can induce hepatic enzymes, so dronabinol exposure may fall and its effect may weaken. Both agents also depress the CNS, so additive drowsiness and impaired psychomotor function can occur.
How serious is the interaction between Butalbital and Dronabinol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor dronabinol response and sedation, and adjust the dronabinol dose accordingly. Advise patients to avoid driving if drowsy.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Disulfiram, Midazolam intranasal. The full list is on the Dronabinol page.
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