Interações medicamentosas
Disulfiram + Dronabinol
Gravidade: Contraindicada
Disulfiram and Dronabinol: contraindicated interaction.
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Resumo
Dronabinol oral solution contains substantial ethanol and propylene glycol. In patients taking disulfiram this can provoke a disulfiram-ethanol reaction with flushing, vomiting, palpitations and hypotension.
O que esta interação significa em palavras simples
Disulfiram and Dronabinol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Por que acontece
Disulfiram inhibits aldehyde dehydrogenase, causing acetaldehyde accumulation from the ethanol in the solution.
O que fazer
Do not use dronabinol oral solution with disulfiram; allow a washout between them as labeled. Consider dronabinol capsules if appropriate.
O que perguntar ao farmacêutico
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Outras interações de Dronabinol
- Cefotetan + Dronabinol Contraindicada
- Dronabinol + Midazolam intranasal Grave
- Dronabinol + Zuranolone Grave
- Amobarbital + Dronabinol Moderada
- Apalutamide + Dronabinol Moderada
- Atazanavir + Dronabinol Moderada
Perguntas frequentes
Can I take Disulfiram with Dronabinol?
MediHelp rates the interaction as contraindicated. Disulfiram and Dronabinol are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Dronabinol oral solution contains substantial ethanol and propylene glycol. In patients taking disulfiram this can provoke a disulfiram-ethanol reaction with flushing, vomiting, palpitations and hypotension.
How serious is the interaction between Disulfiram and Dronabinol?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use dronabinol oral solution with disulfiram; allow a washout between them as labeled. Consider dronabinol capsules if appropriate.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Midazolam intranasal, Zuranolone. The full list is on the Dronabinol page.
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