Interações medicamentosas
Calcium Carbonate + Cholecalciferol
Gravidade: Moderada
Calcium Carbonate and Cholecalciferol: moderate interaction.
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Resumo
Vitamin D increases intestinal calcium absorption, so combining it with calcium supplements can raise serum and urinary calcium. At usual doses the combination is intended and safe, but excessive doses or predisposing conditions can cause hypercalcemia, hypercalciuria and kidney stones.
O que esta interação significa em palavras simples
Calcium Carbonate and Cholecalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Calcium Carbonate belongs to Gastrointestinal Tract; Cholecalciferol belongs to Musculoskeletal.
Por que acontece
Pharmacodynamic: cholecalciferol, via calcitriol, enhances active intestinal calcium absorption, adding to the calcium supplied by calcium carbonate.
O que fazer
Use the lowest doses that meet requirements and avoid combined excessive intake from diet, supplements and fortified products. Monitor serum calcium, and urinary calcium or renal function where there is a history of stones, CKD or high-dose vitamin D.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Referências
- Calcium carbonate and cholecalciferol chewable tablets SmPC - Special Warnings and Interactions — EMA SmPC
Outras interações de Calcium Carbonate
Outras interações de Cholecalciferol
- Cholecalciferol + Digoxin Grave
- Aluminum hydroxide + Cholecalciferol Moderada
- Calcium acetate + Cholecalciferol Moderada
- Calcium chloride + Cholecalciferol Moderada
- Calcium citrate + Cholecalciferol Moderada
- Calcium gluconate + Cholecalciferol Moderada
Perguntas frequentes
Can I take Calcium Carbonate with Cholecalciferol?
MediHelp rates the interaction as moderate. Calcium Carbonate and Cholecalciferol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vitamin D increases intestinal calcium absorption, so combining it with calcium supplements can raise serum and urinary calcium. At usual doses the combination is intended and safe, but excessive doses or predisposing conditions can cause hypercalcemia, hypercalciuria and kidney stones.
How serious is the interaction between Calcium Carbonate and Cholecalciferol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest doses that meet requirements and avoid combined excessive intake from diet, supplements and fortified products. Monitor serum calcium, and urinary calcium or renal function where there is a history of stones, CKD or high-dose vitamin D.
What other medicines interact with Calcium Carbonate?
MediHelp also lists interactions of Calcium Carbonate with, for example, Acalabrutinib, Alendronate, Amlodipine-hydrochlorothiazide-valsartan. The full list is on the Calcium Carbonate page.
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