Interações medicamentosas
Candesartan + Hydrochlorothiazide-lisinopril
Gravidade: Grave
Candesartan and Hydrochlorothiazide-lisinopril: major interaction.
Última atualização Fontes: US FDA label
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Resumo
Combining an ARB with an ACE inhibitor gives dual renin-angiotensin blockade, which increases the risk of hypotension, hyperkalemia and acute kidney injury without clear outcome benefit. Hydrochlorothiazide only partly offsets the potassium rise.
O que esta interação significa em palavras simples
Candesartan and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Candesartan belongs to Cardiovascular; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Por que acontece
Dual blockade of the renin-angiotensin-aldosterone system at two points.
O que fazer
Avoid combining an ARB with lisinopril except in specialist-supervised situations. If used, monitor potassium and creatinine closely.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicada
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicada
- Amifostine + Hydrochlorothiazide-lisinopril Grave
- Amiloride + Hydrochlorothiazide-lisinopril Grave
- Benazepril + Hydrochlorothiazide-lisinopril Grave
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Grave
Outras interações de Candesartan
- Aliskiren + Candesartan Contraindicada
- Candesartan + Sparsentan Contraindicada
- Amifostine + Candesartan Grave
- Amiloride + Candesartan Grave
- Amlodipine-benazepril + Candesartan Grave
- Amlodipine-hydrochlorothiazide-valsartan + Candesartan Grave
Perguntas frequentes
Can I take Candesartan with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as major. Candesartan and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining an ARB with an ACE inhibitor gives dual renin-angiotensin blockade, which increases the risk of hypotension, hyperkalemia and acute kidney injury without clear outcome benefit. Hydrochlorothiazide only partly offsets the potassium rise.
How serious is the interaction between Candesartan and Hydrochlorothiazide-lisinopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining an ARB with lisinopril except in specialist-supervised situations. If used, monitor potassium and creatinine closely.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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