Interações medicamentosas
Benazepril + Hydrochlorothiazide-lisinopril
Gravidade: Grave
Benazepril and Hydrochlorothiazide-lisinopril: major interaction.
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Resumo
Benazepril duplicates the ACE inhibitor lisinopril, giving no added benefit and increasing the risk of hypotension, hyperkalemia and acute kidney injury. Dual ACE inhibitor therapy should not be used.
O que esta interação significa em palavras simples
Benazepril and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Benazepril belongs to Cardiovascular; Hydrochlorothiazide-lisinopril belongs to Cardiovascular.
Por que acontece
Therapeutic duplication causing excessive ACE inhibition and reduced angiotensin II and aldosterone.
O que fazer
Avoid combining two ACE inhibitors and discontinue one. Monitor blood pressure, creatinine and potassium after the change.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicada
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicada
- Amifostine + Hydrochlorothiazide-lisinopril Grave
- Amiloride + Hydrochlorothiazide-lisinopril Grave
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Grave
- Candesartan + Hydrochlorothiazide-lisinopril Grave
Outras interações de Benazepril
- Aliskiren + Benazepril Contraindicada
- Benazepril + Sacubitril / valsartan Contraindicada
- Benazepril + Sacubitril-valsartan Contraindicada
- Amifostine + Benazepril Grave
- Amiloride + Benazepril Grave
- Amlodipine-hydrochlorothiazide-valsartan + Benazepril Grave
Perguntas frequentes
Can I take Benazepril with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as major. Benazepril and Hydrochlorothiazide-lisinopril can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benazepril duplicates the ACE inhibitor lisinopril, giving no added benefit and increasing the risk of hypotension, hyperkalemia and acute kidney injury. Dual ACE inhibitor therapy should not be used.
How serious is the interaction between Benazepril and Hydrochlorothiazide-lisinopril?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two ACE inhibitors and discontinue one. Monitor blood pressure, creatinine and potassium after the change.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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