Interações medicamentosas
Candesartan-hydrochlorothiazide + Ethacrynic acid
Gravidade: Grave
Candesartan-hydrochlorothiazide and Ethacrynic acid: major interaction.
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Resumo
Ethacrynic acid is a potent loop diuretic and combining it with a thiazide can cause marked diuresis, volume depletion, hypotension, hypokalemia and hyponatremia. Candesartan may add to hypotension and renal impairment in volume-depleted patients.
O que esta interação significa em palavras simples
Candesartan-hydrochlorothiazide and Ethacrynic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Candesartan-hydrochlorothiazide belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Por que acontece
Sequential nephron blockade with a loop diuretic and a thiazide produces additive natriuresis and potassium loss.
O que fazer
Monitor electrolytes, renal function, weight and blood pressure closely, and reduce diuretic doses if volume depletion develops. Replace potassium and magnesium as needed.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Candesartan-hydrochlorothiazide
- Aliskiren + Candesartan-hydrochlorothiazide Contraindicada
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicada
- Candesartan-hydrochlorothiazide + Sparsentan Contraindicada
- Acemetacin + Candesartan-hydrochlorothiazide Grave
- Amifostine + Candesartan-hydrochlorothiazide Grave
- Amiloride + Candesartan-hydrochlorothiazide Grave
Outras interações de Ethacrynic acid
Perguntas frequentes
Can I take Candesartan-hydrochlorothiazide with Ethacrynic acid?
MediHelp rates the interaction as major. Candesartan-hydrochlorothiazide and Ethacrynic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ethacrynic acid is a potent loop diuretic and combining it with a thiazide can cause marked diuresis, volume depletion, hypotension, hypokalemia and hyponatremia. Candesartan may add to hypotension and renal impairment in volume-depleted patients.
How serious is the interaction between Candesartan-hydrochlorothiazide and Ethacrynic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, renal function, weight and blood pressure closely, and reduce diuretic doses if volume depletion develops. Replace potassium and magnesium as needed.
What other medicines interact with Candesartan-hydrochlorothiazide?
MediHelp also lists interactions of Candesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Candesartan-hydrochlorothiazide page.
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