Interações medicamentosas
Captopril-hydrochlorothiazide + Ethacrynic acid
Gravidade: Grave
Captopril-hydrochlorothiazide and Ethacrynic acid: major interaction.
Última atualização Fontes: US FDA label
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Resumo
Ethacrynic acid is a potent loop diuretic that, with hydrochlorothiazide, produces sequential nephron blockade with marked diuresis and loss of potassium, sodium and magnesium. Together with an ACE inhibitor this may cause severe hypotension and acute kidney injury, particularly in volume-depleted patients.
O que esta interação significa em palavras simples
Captopril-hydrochlorothiazide and Ethacrynic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Ethacrynic acid belongs to Cardiovascular.
Por que acontece
Additive natriuresis and electrolyte wasting from loop and thiazide diuretics, plus ACE inhibitor reduction of glomerular filtration pressure in volume depletion.
O que fazer
Monitor blood pressure, volume status, electrolytes and creatinine closely, particularly in the first days. Reduce or hold the diuretics if hypotension, hypokalemia or rising creatinine occurs.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Referências
Outras interações de Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicada
- Captopril-hydrochlorothiazide + Dofetilide Contraindicada
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicada
- Aceclofenac + Captopril-hydrochlorothiazide Grave
- Aldesleukin + Captopril-hydrochlorothiazide Grave
- Amifostine + Captopril-hydrochlorothiazide Grave
Outras interações de Ethacrynic acid
Perguntas frequentes
Can I take Captopril-hydrochlorothiazide with Ethacrynic acid?
MediHelp rates the interaction as major. Captopril-hydrochlorothiazide and Ethacrynic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ethacrynic acid is a potent loop diuretic that, with hydrochlorothiazide, produces sequential nephron blockade with marked diuresis and loss of potassium, sodium and magnesium. Together with an ACE inhibitor this may cause severe hypotension and acute kidney injury, particularly in volume-depleted patients.
How serious is the interaction between Captopril-hydrochlorothiazide and Ethacrynic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, volume status, electrolytes and creatinine closely, particularly in the first days. Reduce or hold the diuretics if hypotension, hypokalemia or rising creatinine occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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