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Interações medicamentosas

Carbamazepine + Dapsone

Gravidade: Moderada

Carbamazepine and Dapsone: moderate interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

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Resumo

Carbamazepine induces CYP3A4 and may lower dapsone concentrations, potentially reducing efficacy. Induction may also increase formation of dapsone hydroxylamine, which can worsen haemolysis and methaemoglobinaemia.

O que esta interação significa em palavras simples

Carbamazepine and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Carbamazepine belongs to Central Nervous System; Dapsone belongs to Anti Bacterial.

Nível de evidência: Low

Por que acontece

CYP3A4 induction by carbamazepine increases dapsone metabolism, including N-hydroxylation.

O que fazer

Monitor clinical response, haemoglobin and methaemoglobin levels, and increase monitoring frequency after carbamazepine starts or stops.

O que perguntar ao farmacêutico

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Carbamazepine with Dapsone?

MediHelp rates the interaction as moderate. Carbamazepine and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces CYP3A4 and may lower dapsone concentrations, potentially reducing efficacy. Induction may also increase formation of dapsone hydroxylamine, which can worsen haemolysis and methaemoglobinaemia.

How serious is the interaction between Carbamazepine and Dapsone?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response, haemoglobin and methaemoglobin levels, and increase monitoring frequency after carbamazepine starts or stops.

What other medicines interact with Dapsone?

MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.

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