Drug interactions
Carbamazepine + Dapsone
Severity: Moderate
Carbamazepine and Dapsone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbamazepine induces CYP3A4 and may lower dapsone concentrations, potentially reducing efficacy. Induction may also increase formation of dapsone hydroxylamine, which can worsen haemolysis and methaemoglobinaemia.
What this interaction means in plain words
Carbamazepine and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Dapsone belongs to Anti Bacterial.
Why it happens
CYP3A4 induction by carbamazepine increases dapsone metabolism, including N-hydroxylation.
What to do
Monitor clinical response, haemoglobin and methaemoglobin levels, and increase monitoring frequency after carbamazepine starts or stops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dapsone
- Bcg vaccine live + Dapsone Major
- Dapsone + Primaquine Major
- Apalutamide + Dapsone Moderate
- Belzutifan + Dapsone Moderate
- Bosentan + Dapsone Moderate
- Bupivacaine implant + Dapsone Moderate
Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Frequently asked questions
Can I take Carbamazepine with Dapsone?
MediHelp rates the interaction as moderate. Carbamazepine and Dapsone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbamazepine induces CYP3A4 and may lower dapsone concentrations, potentially reducing efficacy. Induction may also increase formation of dapsone hydroxylamine, which can worsen haemolysis and methaemoglobinaemia.
How serious is the interaction between Carbamazepine and Dapsone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response, haemoglobin and methaemoglobin levels, and increase monitoring frequency after carbamazepine starts or stops.
What other medicines interact with Dapsone?
MediHelp also lists interactions of Dapsone with, for example, Bcg vaccine live, Primaquine, Apalutamide. The full list is on the Dapsone page.
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