Interações medicamentosas
Carbamazepine + Propylthiouracil
Gravidade: Grave
Carbamazepine and Propylthiouracil: major interaction.
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Resumo
Both drugs can cause agranulocytosis, so combined use may heighten the risk of severe neutropenia and infection.
O que esta interação significa em palavras simples
Carbamazepine and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carbamazepine belongs to Central Nervous System; Propylthiouracil belongs to Endocrine.
Por que acontece
Additive pharmacodynamic myelotoxicity, as each drug independently can cause idiosyncratic agranulocytosis.
O que fazer
Check a baseline and periodic white cell count with differential, and counsel the patient to report fever or sore throat at once. Stop the offending drug if neutropenia develops, and consider an alternative anticonvulsant.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicada
- Cabotegravir + Carbamazepine Contraindicada
- Carbamazepine + Delamanid Contraindicada
- Carbamazepine + Dienogest / estradiol valerate Contraindicada
- Carbamazepine + Doravirine Contraindicada
- Carbamazepine + Elbasvir / grazoprevir Contraindicada
Outras interações de Propylthiouracil
Perguntas frequentes
Can I take Carbamazepine with Propylthiouracil?
MediHelp rates the interaction as major. Carbamazepine and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause agranulocytosis, so combined use may heighten the risk of severe neutropenia and infection.
How serious is the interaction between Carbamazepine and Propylthiouracil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline and periodic white cell count with differential, and counsel the patient to report fever or sore throat at once. Stop the offending drug if neutropenia develops, and consider an alternative anticonvulsant.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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