Interações medicamentosas
Clozapine + Propylthiouracil
Gravidade: Grave
Clozapine and Propylthiouracil: major interaction.
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Resumo
Both drugs can cause agranulocytosis, and using them together may increase the risk of severe neutropenia and infection.
O que esta interação significa em palavras simples
Clozapine and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Clozapine belongs to Central Nervous System; Propylthiouracil belongs to Endocrine.
Por que acontece
Additive risk of bone marrow suppression and immune-mediated agranulocytosis.
O que fazer
Avoid the combination where possible and consider non-drug thyroid treatments. If used, monitor absolute neutrophil count closely and stop for neutropenia.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Clozapine
- Clozapine + Deferiprone Contraindicada
- Clozapine + Irinotecan Contraindicada
- Clozapine + Pimozide Contraindicada
- Clozapine + Thioridazine Contraindicada
- Acalabrutinib + Clozapine Grave
- Adagrasib + Clozapine Grave
Outras interações de Propylthiouracil
Perguntas frequentes
Can I take Clozapine with Propylthiouracil?
MediHelp rates the interaction as major. Clozapine and Propylthiouracil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause agranulocytosis, and using them together may increase the risk of severe neutropenia and infection.
How serious is the interaction between Clozapine and Propylthiouracil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and consider non-drug thyroid treatments. If used, monitor absolute neutrophil count closely and stop for neutropenia.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
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