Interações medicamentosas
Carboplatin + Olaparib
Gravidade: Grave
Carboplatin and Olaparib: major interaction.
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Resumo
Olaparib commonly causes anemia, neutropenia and thrombocytopenia, and carboplatin adds substantial bone marrow toxicity. Combining them can produce more frequent and prolonged cytopenias that often require dose modification.
O que esta interação significa em palavras simples
Carboplatin and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carboplatin belongs to Oncology; Olaparib belongs to Oncology.
Por que acontece
Additive myelosuppression from a PARP inhibitor and a DNA-damaging platinum agent.
O que fazer
Monitor complete blood counts frequently, especially early in treatment, and interrupt or reduce doses for significant cytopenias. Use supportive care such as transfusions or growth factors when needed.
O que perguntar ao farmacêutico
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Outras interações de Carboplatin
Outras interações de Olaparib
- Amiodarone + Olaparib Grave
- Amobarbital + Olaparib Grave
- Apalutamide + Olaparib Grave
- Aprepitant + Olaparib Grave
- Azathioprine + Olaparib Grave
- Carbamazepine + Olaparib Grave
Perguntas frequentes
Can I take Carboplatin with Olaparib?
MediHelp rates the interaction as major. Carboplatin and Olaparib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olaparib commonly causes anemia, neutropenia and thrombocytopenia, and carboplatin adds substantial bone marrow toxicity. Combining them can produce more frequent and prolonged cytopenias that often require dose modification.
How serious is the interaction between Carboplatin and Olaparib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts frequently, especially early in treatment, and interrupt or reduce doses for significant cytopenias. Use supportive care such as transfusions or growth factors when needed.
What other medicines interact with Carboplatin?
MediHelp also lists interactions of Carboplatin with, for example, Adenovirus types 4 and 7 live, Amikacin, Amphotericin b deoxycholate. The full list is on the Carboplatin page.
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