Interações medicamentosas
Cefiderocol + Streptomycin
Gravidade: Moderada
Cefiderocol and Streptomycin: moderate interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Streptomycin is nephrotoxic and ototoxic, and any decline in kidney function raises its exposure. Cefiderocol has little direct nephrotoxicity, so the added risk is modest and mainly from renal changes in sick patients.
O que esta interação significa em palavras simples
Cefiderocol and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefiderocol belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
Por que acontece
Possible additive nephrotoxicity, with reduced renal clearance of streptomycin if kidney function declines.
O que fazer
Monitor serum creatinine and streptomycin levels, and adjust the streptomycin dose to renal function. Watch for hearing loss or vestibular symptoms.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Streptomycin
Outras interações de Cefiderocol
- Amikacin + Cefiderocol Moderada
- Cefiderocol + Warfarin Moderada
- Cefiderocol + Dexamethasone-tobramycin Leve
- Cefiderocol + Gentamicin Leve
Perguntas frequentes
Can I take Cefiderocol with Streptomycin?
MediHelp rates the interaction as moderate. Cefiderocol and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Streptomycin is nephrotoxic and ototoxic, and any decline in kidney function raises its exposure. Cefiderocol has little direct nephrotoxicity, so the added risk is modest and mainly from renal changes in sick patients.
How serious is the interaction between Cefiderocol and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and streptomycin levels, and adjust the streptomycin dose to renal function. Watch for hearing loss or vestibular symptoms.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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