Interações medicamentosas
Cefotetan + Streptomycin
Gravidade: Moderada
Cefotetan and Streptomycin: moderate interaction.
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Resumo
Streptomycin is nephrotoxic and ototoxic, and cephalosporins have been reported to add to aminoglycoside kidney injury in some patients. Renal impairment would then raise streptomycin levels and the risk of ototoxicity.
O que esta interação significa em palavras simples
Cefotetan and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefotetan belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
Por que acontece
Possible additive nephrotoxicity, with reduced renal clearance of streptomycin if kidney function declines.
O que fazer
Monitor serum creatinine and streptomycin levels, and adjust the streptomycin dose to renal function. Watch for hearing loss or vestibular symptoms.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Streptomycin
Outras interações de Cefotetan
- Cefotetan + Dronabinol Contraindicada
- Cefotetan + Warfarin Grave
- Amikacin + Cefotetan Moderada
- Argatroban + Cefotetan Moderada
- Cefotetan + Dalteparin Moderada
- Cefotetan + Enoxaparin Moderada
Perguntas frequentes
Can I take Cefotetan with Streptomycin?
MediHelp rates the interaction as moderate. Cefotetan and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Streptomycin is nephrotoxic and ototoxic, and cephalosporins have been reported to add to aminoglycoside kidney injury in some patients. Renal impairment would then raise streptomycin levels and the risk of ototoxicity.
How serious is the interaction between Cefotetan and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and streptomycin levels, and adjust the streptomycin dose to renal function. Watch for hearing loss or vestibular symptoms.
What other medicines interact with Streptomycin?
MediHelp also lists interactions of Streptomycin with, for example, Abobotulinumtoxina, Adefovir, Amikacin. The full list is on the Streptomycin page.
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