Interações medicamentosas
Cefoxitin + Gentamicin
Gravidade: Moderada
Cefoxitin and Gentamicin: moderate interaction.
Última atualização
Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.
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Resumo
Concurrent use of a cephalosporin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with other risk factors. Aminoglycoside ototoxicity may also be a concern with prolonged exposure. The effect is generally manageable.
O que esta interação significa em palavras simples
Cefoxitin and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefoxitin belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.
Por que acontece
Additive nephrotoxic potential, with aminoglycoside tubular toxicity possibly being aggravated by cephalosporins.
O que fazer
Monitor serum creatinine and gentamicin trough levels during combined therapy, and keep the aminoglycoside course as short as possible. Ensure adequate hydration and avoid other nephrotoxins.
O que perguntar ao farmacêutico
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Outras interações de Cefoxitin
- Amikacin + Cefoxitin Moderada
- Aztreonam + Cefoxitin Moderada
- Bcg vaccine live + Cefoxitin Moderada
- Cefoxitin + Chloramphenicol Moderada
- Cefoxitin + Cholera vaccine Moderada
- Cefoxitin + Dexamethasone-tobramycin Moderada
Outras interações de Gentamicin
Perguntas frequentes
Can I take Cefoxitin with Gentamicin?
MediHelp rates the interaction as moderate. Cefoxitin and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of a cephalosporin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with other risk factors. Aminoglycoside ototoxicity may also be a concern with prolonged exposure. The effect is generally manageable.
How serious is the interaction between Cefoxitin and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin trough levels during combined therapy, and keep the aminoglycoside course as short as possible. Ensure adequate hydration and avoid other nephrotoxins.
What other medicines interact with Cefoxitin?
MediHelp also lists interactions of Cefoxitin with, for example, Amikacin, Aztreonam, Bcg vaccine live. The full list is on the Cefoxitin page.
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