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Interações medicamentosas

Aztreonam + Cefoxitin

Gravidade: Moderada

Aztreonam and Cefoxitin: moderate interaction.

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Para profissionais de saúde — apenas referência. Esta página é um resumo breve, não é aconselhamento médico nem substitui a bula oficial ou o julgamento clínico. Verifique sempre antes de prescrever ou dispensar.

O conteúdo clínico desta página está disponível apenas em inglês.

Resumo

Cefoxitin can induce chromosomal beta-lactamases in some Gram-negative bacteria such as Enterobacter and Pseudomonas, which may reduce aztreonam activity. This is an in vitro antagonism, and its clinical relevance is uncertain.

O que esta interação significa em palavras simples

Aztreonam and Cefoxitin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.

Aztreonam belongs to Anti Bacterial; Cefoxitin belongs to Anti Bacterial.

Nível de evidência: Low

Por que acontece

Cefoxitin induces inducible beta-lactamase production in some Gram-negative bacteria, which can hydrolyze aztreonam.

O que fazer

Avoid pairing the two when treating organisms known to produce inducible beta-lactamases. Guide therapy by culture and susceptibility results.

O que perguntar ao farmacêutico

  • Should I take them at different times of day?
  • Does the dose of either medicine need to change?
  • Is there anything I should avoid, such as alcohol or certain foods, while on both?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Perguntas frequentes

Can I take Aztreonam with Cefoxitin?

MediHelp rates the interaction as moderate. Aztreonam and Cefoxitin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefoxitin can induce chromosomal beta-lactamases in some Gram-negative bacteria such as Enterobacter and Pseudomonas, which may reduce aztreonam activity. This is an in vitro antagonism, and its clinical relevance is uncertain.

How serious is the interaction between Aztreonam and Cefoxitin?

MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pairing the two when treating organisms known to produce inducible beta-lactamases. Guide therapy by culture and susceptibility results.

What other medicines interact with Cefoxitin?

MediHelp also lists interactions of Cefoxitin with, for example, Amikacin, Bcg vaccine live, Chloramphenicol. The full list is on the Cefoxitin page.

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